Всероссийский научный журнал "Вопросы права"2949-0871OtherВлияние лазерного воздействия на биологические свойства винил-фосфонатовПилипАнна ГеоргиевнаPilipAnna Georgievnaanyta_273@mail.ruЕгороваАнастасия ВалерьевнаEgorovaAnastasia Valerievnadiekerze54@gmail.comЛобоваАнастасия МихайловнаLobovaAnastasia Mikhailovnaanlbv9500@mail.ruБикбаеваГулия ИльнуровнаBikbaevaGuliya Ilnurovnast086467@student.spbu.ruМаньшинаАлина АнвяровнаManshinaAlina Anvyarovnast086467@student.spbu.ruResearcher, St. Petersburg Federal Research Center of the Russian Academy of Sciences (SPC RAS)Научный сотрудник, Санкт-Петербургский федеральный исследовательский центр Российской академии наук (ФИЦ РАН)Senior Researcher, St. Petersburg Federal Research Center of the Russian Academy of Sciences (SPC RAS)к.х.н, Старший научный сотрудник, Санкт-Петербургский федеральный исследовательский центр Российской академии наук (ФИЦ РАН)Master’s degree, Saint Petersburg State Institute of Technology (Technical University) Химические науки 1.4.9Магистр, Санкт-Петербургский Государственный Технологический Институт (Технический Университет)PhD, Institute of Chemistry, Saint-Petersburg State UniversityАспирант, Институт химии Санкт-Петербургского государственного университетаProfessor, Institute of Chemistry, Saint-Petersburg State UniversityД.х.н., Профессор, Институт химии Санкт-Петербургского государственного университета3006202421341402603202427062024

В данной работе изучалось влияние облучения с длинами волн 266 и 325 нм на изменение биологической активности вини-фосфонатов - диалкил (Z)-(2-хлор-2-фенилвинил)фосфонат, с потенциальным применением в качестве ингибитора бутирилхолинэстеразы.

In this work, we studied the effect of irradiation with wavelengths of 266 and 325 nm on changes in the biological activity of vinyl phosphonates - dialkyl (Z)-(2-chloro-2-phenylvinyl)phosphonate, with potential use as an inhibitor of butyrylcholinesterase.

биологическая активностьингибирование бутирилхолинэстеразывинил фосфонатылазерная химияфотофармакологияbiological activitybutyrylcholinesterase inhibitionvinyl phosphonateslaser chemistryphotopharmacologyRyazantsev M.N., Strashkov D.M., Nikolaev D.M, Shtyrov A.A., Panov M.S. Photopharmacological compounds based on azobenzenes and azoheteroarenes: principles of molecular design, molecular modelling, and synthesis // Russ Chem Rev. 2021. 90 (7). Pp. 868–893. DOI: https://doi.org/10.1070/RCR5001Bregestovski P., Maleeva G., Gorostiza P. Light-induced regulation of ligand-gated channel activity // Br J Pharmacol. 2018. 175(11). Pp. 1892-1902. doi: 10.1111/bph.14022.Lerch M.M., Hansen M.J., van Dam G.M., Szymanski W., Feringa B.L. Emerging Targets in Photopharmacology // Angew Chem Int Ed Engl. 2016. 55(37). Pp. 10978-99. doi: 10.1002/anie.201601931.Barber D.M., Liu S.-A., Gottschling K., Sumse M., Hollmann M., Trauner D. Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist // Chemical Science. 2017. 8(1). Pp. 611–615. doi:10.1039/c6sc01621a.Raster P., Schmidt A., Rambow M., Kuzmanovic N., König B., Hilt G. Immobilisation of photoswitchable diarylcyclohexenes synthesised via cobalt-mediated Diels–Alder reaction // Chem. Commun. 2014. 50(15). Pp. 1864–1866. doi:10.1039/c3cc48487d.Schilling L.-H., Stock N. High-throughput ultrasonic synthesis and in situ crystallisation investigation of metal phosphonocarboxylates // Dalton Trans. 2014. 43(2). Pp. 414–422. doi:10.1039/c3dt52576g.Ruangritchankul S., Chantharit P., Srisuma S., Gray L.C. Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review // Ther Clin Risk Manag. 2021. 17. Pp. 927-949 doi:10.2147/TCRM.S323387.Todorov A., Torah R., Ardern-Jones M.R., Beeby S.P. Electromagnetic Sensing Techniques for Monitoring Atopic Dermatitis—Current Practices and Possible Advancements: A Review // Sensors. 2023. 23. Pp. 3935. doi:10.3390/s23083935.Wessler I., Reinheimer T., Kilbinger H., Bittinger F., Kirkpatrick C.J., Saloga J., Knop J. Increased acetylcholine levels in skin biopsies of patients with atopic dermatitis // Life Sciences. 2003. 72 (18–19). Pp. 2169-2172. doi: 10.1016/S0024-3205(03)00079-1.Stegemann A., Böhm M. Targeting the α7 nicotinic acetylcholine receptor–A novel road towards the future treatment of skin diseases // Exp Dermatol. 2020. 29. Pp. 924–931. doi:10.1111/exd.14173Pankin D, Khokhlov A., Kolesnikov I., Vasileva A., Pilip A., Egorova A., Erkhitueva E., Zigel V., Gureev M., Manshina A. Laser-induced twisting of phosphorus functionalized thiazolotriazole as a way of cholinesterase activity change // Spectrochim. Acta - A: Mol. Biomol. 2021. 246. Pp. 118979. doi: 10.1016/j.saa.2020.118979.Kolesnikov I., Pankin D., Khokhlov A., Pilip A., Egorova A., Zigel V., Gureev M., Manshina A., Leuchsef G. Laser-induced switching of the biological activity of phosphonate molecules // New J. Chem. 2021. 45. Pp. 15195-15199. doi: 10.1039/D1NJ02487FEgorova A.V., Egorov D.M., Sonin N.O., Kolesnikov I. E., Pankin D. V., Manshina A. A., Baichurin R. I. Synthesis of a New Series of β-Chloro-β-phenylvinylphosphonic Acid Chloride Derivatives // Russ. J. Gen. Chem. 2022. 92. Pp. 2191–2196. doi:10.1134/S1070363222100322Dontsova E.A. Screen-printed carbon electrode for choline based on MnO2 nanoparticles and choline oxidase/polyelectrolyte layers // Sensors Actuators B Chem. 2011. 159 (1). Pp. 261–270.Eremenko A. V. Planar thiol-sensitive sensor elements for the determination of butyrylcholinesterase activity and analysis of its inhibitors // Moscow Univ. Chem. Bull. 2014. 69(3). P. 131–135.Ryazantsev M.N., Strashkov D.M., Nikolaev D.M, Shtyrov A.A., Panov M.S. Photopharmacological compounds based on azobenzenes and azoheteroarenes: principles of molecular design, molecular modelling, and synthesis // Russ Chem Rev. 2021. 90 (7). Pp. 868–893. DOI: https://doi.org/10.1070/RCR5001Bregestovski P., Maleeva G., Gorostiza P. Light-induced regulation of ligand-gated channel activity // Br J Pharmacol. 2018. 175(11). Pp. 1892-1902. doi: 10.1111/bph.14022.Lerch M.M., Hansen M.J., van Dam G.M., Szymanski W., Feringa B.L. Emerging Targets in Photopharmacology // Angew Chem Int Ed Engl. 2016. 55(37). Pp. 10978-99. doi: 10.1002/anie.201601931.Barber D.M., Liu S.-A., Gottschling K., Sumse M., Hollmann M., Trauner D. Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist // Chemical Science. 2017. 8(1). Pp. 611–615. doi:10.1039/c6sc01621a.Raster P., Schmidt A., Rambow M., Kuzmanovic N., König B., Hilt G. Immobilisation of photoswitchable diarylcyclohexenes synthesised via cobalt-mediated Diels–Alder reaction // Chem. Commun. 2014. 50(15). Pp. 1864–1866. doi:10.1039/c3cc48487d.Schilling L.-H., Stock N. High-throughput ultrasonic synthesis and in situ crystallisation investigation of metal phosphonocarboxylates // Dalton Trans. 2014. 43(2). Pp. 414–422. doi:10.1039/c3dt52576g.Ruangritchankul S., Chantharit P., Srisuma S., Gray L.C. Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review // Ther Clin Risk Manag. 2021. 17. Pp. 927-949 doi:10.2147/TCRM.S323387.Todorov A., Torah R., Ardern-Jones M.R., Beeby S.P. Electromagnetic Sensing Techniques for Monitoring Atopic Dermatitis—Current Practices and Possible Advancements: A Review // Sensors. 2023. 23. Pp. 3935. doi:10.3390/s23083935.Wessler I., Reinheimer T., Kilbinger H., Bittinger F., Kirkpatrick C.J., Saloga J., Knop J. Increased acetylcholine levels in skin biopsies of patients with atopic dermatitis // Life Sciences. 2003. 72 (18–19). Pp. 2169-2172. doi: 10.1016/S0024-3205(03)00079-1.Stegemann A., Böhm M. Targeting the α7 nicotinic acetylcholine receptor–A novel road towards the future treatment of skin diseases // Exp Dermatol. 2020. 29. Pp. 924–931. doi:10.1111/exd.14173Pankin D, Khokhlov A., Kolesnikov I., Vasileva A., Pilip A., Egorova A., Erkhitueva E., Zigel V., Gureev M., Manshina A. Laser-induced twisting of phosphorus functionalized thiazolotriazole as a way of cholinesterase activity change // Spectrochim. Acta - A: Mol. Biomol. 2021. 246. Pp. 118979. doi: 10.1016/j. saa.2020.118979.Kolesnikov I., Pankin D., Khokhlov A., Pilip A., Egorova A., Zigel V., Gureev M., Manshina A., Leuchsef G. Laser-induced switching of the biological activity of phosphonate molecules // New J. Chem. 2021. 45. Pp. 15195-15199. doi: 10.1039/D1NJ02487FEgorova A.V., Egorov D.M., Sonin N.O., Kolesnikov I. E., Pankin D. V., Manshina A. A., Baichurin R. I. Synthesis of a New Series of β-Chloro-β-phenylvinylphosphonic Acid Chloride Derivatives // Russ. J. Gen. Chem. 2022. 92. Pp. 2191–2196. doi:10.1134/S1070363222100322Dontsova E.A. Screen-printed carbon electrode for choline based on MnO2 nanoparticles and choline oxidase/polyelectrolyte layers // Sensors Actuators B Chem. 2011. 159 (1). Pp. 261–270.Eremenko A. V. Planar thiol-sensitive sensor elements for the determination of butyrylcholinesterase activity and analysis of its inhibitors // Moscow Univ. Chem. Bull. 2014. 69(3). P. 131–135.